SileksMagNA-Direct™ circulating nucleic acid Isolation kit, 2 mL sample volume

The kit is designed for the isolation of circulating nucleic acid from plasma or serum.

Most of the DNA and RNA in the body is contained within cells. A small amount of nucleic acids is found circulating freely in the blood.

These DNA and RNA molecules are formed both during the destruction of cells and during the normal secretory activity of cells, during which extracellular vesicles (exosomes and others) are formed, and these vesicles are released into the bloodstream. Viruses and bacteria in the bloodstream can also serve as a source of circulating nucleic acids.

The presence of such free circulating DNA and RNA allows the use of minimally invasive diagnostic methods to detect a number of clinical diseases and disorders. The detection of specific DNA and RNA gives a unique potential for early diagnosis of various pathologies.

Using circulating nucleic acid analysis, you can detect early cancer, viral infections, perform non-invasive perinatal diagnostics during pregnancy, detect various forms of diabetes, and much more.

In urine, nucleic acids are found mainly in exosomes. In this form, they are well stored. This makes it possible for the non-invasive diagnosis of a whole range of clinical diseases and disorders.

Depending on the task, different amounts of starting material can be used - from 100 μL up to 10 mL of plasma or serum.

For large volumes, we recommend to use the MagRack 50ML large magnetic tube rack.